Biomedical Applications Of Silver Nanoparticles
Ashutosh Debata and
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Shikha Behera: P.L.Nayak Research Foundation, Neelachal Bhavan, Cuttack- 753004, Odisha, India
Ashutosh Debata: Principal, Stewart Science College, Cuttack-753001, Odisha
P.L.Nayak: P.L.Nayak Research Foundation, Neelachal Bhavan, Cuttack- 753004, Odisha, India
Journal of Asian Scientific Research, 2011, vol. 1, issue 1, pages 27-56
Nanotechnology is expected to open some new aspects to fight and prevent diseases using atomic scale tailoring of materials. The ability to uncover the structure and function of bio systems at the nano scale, stimulates research leading to improvement in biology, biotechnology, medicine and healthcare.The size of nano materials is similar to that of most biological molecules and structures; therefore, nano materials can be useful for both in vivo and in vitrobiomedical research and applications. The integration of nanomaterials withbiology has led to the development of diagnostic devices, contrast agents,analytical tools, physical therapy applications, and drug delivery vehicles .There is an increasing commercial demand for nano particles due to their wide applicability in various areas such as electronics, catalysis, chemistry, energy,and medicine. Metallic nano particles are traditionally synthesized by wetchemical techniques, where the chemicals used are quite often toxic and flammable. Nano-silver is used in an increasing number of products. Some of the applications have resulted in the concern of governments and the public,since little is known about the potential risks of nano-silver. In this review, an inventory is made to identify knowledge gaps that have to be filled before risks for both man and the environment can be assessed as reliable as for‘non-nanosized’ chemicals. It is hypothesized that the toxic effects of nanosilverare due to a combination of the specific properties of silvernanoparticles and the generation of ions from them. The main topic for future research is validation of our ‘0-hypothesis’ that toxic effects of nano-silverare proportional to the activity of free silver ions released by then anoparticles. Furthermore, it must be determined whether or to what extent nano-silver particles will enter the body. The outcomes of these tests will determine the requirements for further toxicity testing.
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