The Neo-Austrian contribution as regards entrepreneurship is inserted within a dynamic setting taking account the regional fact. An introduction to the Kirznerian theory of entrepreneurship is first proposed. We deal more specifically with the concept of vigilance, the absence of entrepreneurial cost from an analytical viewpoint, and the costs and incomes expected from entrepreneurial action, relative to other kinds of activities, in situation of incomplete system of markets. The occupational choice by individuals and the effects of entrepreneurship on economic growth are then discussed since the regional dimension of economic activities is introduced into the argumentation. A systemic approach of occupational choice and growth results in highlighting that the effects of entrepreneurial action on economic growth cannot be considered without difficulty independently of the feed-back effects on the individual occupational choice parameters, a fortiori in reference to a whole set of localized economic resources and activities in interrelationship or interaction.