This paper describes the first direct application of the Payback Framework (PF) in the United States for an evaluation of the Mind-Body Interactions and Health Program, a trans-National Institutes of Health program funded over a ten-year period beginning in 1999. The program funded 15 research centers and 44 investigator-initiated research projects. We present results from an initial planning study and describe how we selected the PF as a conceptual framework for an outcome evaluation of the program. We outline the overall design for the outcome evaluation study and describe how we adapted the PF with reference to the initial phase of the study focusing in the 15 research centers. Copyright , Beech Tree Publishing.