The Design of Cluster Randomized Crossover Trials

Charlotte Rietbergen and Mirjam Moerbeek
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Charlotte Rietbergen: Â
Mirjam Moerbeek: Utrecht University

Journal of Educational and Behavioral Statistics, 2011, vol. 36, issue 4, pages 472-490

Abstract: The inefficiency induced by between-cluster variation in cluster randomized (CR) trials can be reduced by implementing a crossover (CO) design. In a simple CO trial, each subject receives each treatment in random order. A powerful characteristic of this design is that each subject serves as its own control. In a CR CO trial, clusters of subjects are randomly allocated to a sequence of interventions. Under this design, each subject is either included in only one of the treatment periods (CO at cluster level) or in both periods (CO at subject level). In this study, the efficiency of both CR CO trials relative to the CR trial without CO is demonstrated. Furthermore, the optimal allocation of clusters and subjects given a fixed budget or desired power level is discussed.

Keywords: cluster randomized crossover design; statistical efficiency; optimal allocation (search for similar items in EconPapers)
Date: 2011
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Persistent link: http://EconPapers.repec.org/RePEc:sae:jedbes:v:36:y:2011:i:4:p:472-490

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