Evaluating the Epidemiology and Morbidity Burden Associated with Human Papillomavirus in Israel: Accounting for CIN1 and Genital Warts in Addition to CIN2/3 and Cervical Cancer

Oren Shavit, Raanan Raz, Michal Stein, Gabriel Chodick, Eduardo Schejter, Yehuda Ben-David, Raanan Cohen, Daphna Arbel and Varda Shalev
Additional contact information
Oren Shavit: The School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel
Raanan Raz: Medical Informatics, Maccabi Healthcare Services, Tel Aviv, Israel
Michal Stein: MSD Israel Co. Ltd, Hod-Hasharon, Israel
Gabriel Chodick: Medical Informatics, Maccabi Healthcare Services, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Eduardo Schejter: Tel-Aviv Womens Health Center, Maccabi Healthcare Services, Tel Aviv, Israel
Yehuda Ben-David: Division of Gynecologic Oncology, HaEmek Medical Center, Afula, Israel
Raanan Cohen: MSD Israel Co. Ltd, Hod-Hasharon, Israel
Daphna Arbel: MSD Israel Co. Ltd, Hod-Hasharon, Israel
Varda Shalev: Medical Informatics, Maccabi Healthcare Services, Tel Aviv, Israel

Applied Health Economics and Health Policy, 2012, vol. 10, issue 2, pages 87-97

Abstract: Background:Background: Human papillomavirus (HPV) infection is mostly associated with cervical cancer (CC). However, it can cause other illnesses as well, all of which impact on people's wellbeing and consume healthcare resources. Measures for prevention or early detection of these conditions differ in their effectiveness and cost. An informative evaluation of the projected benefit of these measures depends on understanding the current unmet need, not only limited to CC. Abstract: Objective:Objective: To evaluate the burden of HPV-related conditions in Israel, including CC, cervical precancerous lesions and genital warts. Abstract: Methods:Methods: A retrospective database analysis was conducted for the second largest health management organization (HMO) in Israel, covering approximately 1.8 million people. Records were drawn following a search for key words indicative of related diagnoses, lab results, medications, or procedures for the time period of 2006-2008. Prevalence, incidence and resource utilization were analysed. Findings were extrapolated to the whole Israeli population using age and gender incidence rates. Abstract: Results:Results: Incidence of CC was found to be 5 per 100 000 females. Incidences of cervical intraepithelial neoplasia (CIN) grades 1, 2 and 3 were 74, 27 and 36 per 100 000 females, respectively. Incidence of genital warts was 239 and 185 per 100 000 for men and women, respectively. The overall annual economic burden was calculated to be $US48 838 058 (year 2010 values). Abstract: Conclusions:Conclusions: HPV poses a significant burden in terms of health (clinical and quality of life) and in monetary terms, even for conditions that are sometimes regarded as benign, such as CIN1 or genital warts. Current findings should be used for proper evaluation of measures to reduce HPV-related morbidity and mortality, such as regular screening and vaccination.

Keywords: Cervical-cancer; Cervical-intraepithelial-neoplasia; Cost-of-illness; Genital-warts; Human-papillomavirus-infections. (search for similar items in EconPapers)
JEL-codes: C D I Z I1 I19 I18 I11 (search for similar items in EconPapers)
Date: 2012
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