In the time where the digital world is moving to mobile devices, new opportunities are emerging for the e-health systems. We live in the time when data are stored in different databases and different ways. This imposed the use of ontologies to resolve interoperability issues. Ontologies can be used for automation of e-health system data flow, enabling automated responses in real time to patient data entered into the medical record from Physicians and hospitals, and by offering caregivers evidence-based, best-practice information about how to act in emergency or nonemergency situations. Mobile e-health semantic systems help Physicians tracking better the health of their patients, avoid mistakes and act faster in emergency situations Semantic technology and database technology in combination with mobile devices together make a combined information system which will revolutionize the way how today’s health institutions treat their patients.