This paper provides the first detailed quantitative analysis of the economic activity of Antioquia for the nineteenth century and early twentieth. From the existing data for the Colombian economy, it is reconstructed one of the first series of regional GDP in Latin America for the period. We find that Antioquia, in the early nineteenth century, enjoyed of higher per capita incomes than the average of Colombia. Moreover, we found periods of economic boom between 1800 and 1840, 1860 and 1880, and 1905 and 1913, the latter being more pronounced. Thus, the paper answers the long discussion about the economic takeoff of Antioquia. It is provided insights into the economic growth of Antioquia without need for institutional or cultural arguments.