This paper continues the empirical research line started by Crepon et al. (1998) about the impact of research and development on innovation and innovation on productivity of firms. In this paper we estimate a structural model using Asymptotic Least Squares (ALS) which corrects for selectivity and simultaneity biases taking in consideration the particular characteristics of the available data. We find that most of the Schumpeterian hypotheses are confirmed: research and innovative activities are related with firm size and market power. However, in the case of Chile, firms productivity is not affected by innovative results nor by research expenditures in the short run.