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An Expression Study Profile of Proinflammatory Cytokines in Asthma Patient

Mustafa Mudhafar and H.A. Alsailawi
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H.A. Alsailawi: Department of Biology, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, Perak, Malaysia.

Journal of Asian Scientific Research, 2019, vol. 9, issue 12, 227-234

Abstract: Over the past years, there has been a remarkable development in the diagnosis and control of asthma. However, despite the development, there are still problems facing people infected with it, classified as a chronic disease. Over 50 cytokines have been identified in asthma and COPD, but their role in the pathophysiology of these complex airway diseases is often unclear. Genetic studies have proved that multiple genes are involved in asthma and these genes code for cytokines. In the present work, the expression levels of Interleukin 4 and Interleukin 17 have been examined with real-time reverse transcriptase PCR. It was found that when compared with normal controls, the expression levels of these cytokines were increased to folds in asthmatic patients. As these cytokines along with other cytokines, interact and result in symptoms of asthma, regulation of these cytokines will provide therapy for asthma. It was found that the levels of these pro-inflammatory cytokines were elevated in the case of asthma patients as compared to controls. This gives evidence that therapy against these cytokines can assist in asthma treatment.

Keywords: Asthma; PCR; RT-PCR; Interleukin 4; Interleukin 17; Cytokines. (search for similar items in EconPapers)
Date: 2019
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