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Effect of Irvingia gabonensis Stem Bark on Liver Function in Sodium Arsenite-Exposed Wistar Rats

Efosa Godwin Ewere, Ngozi Paulinus Okolie, Gerald Ikechi Eze and Samson Adewale Oyebadejo
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Efosa Godwin Ewere: Department of Biochemistry, University of Uyo, Uyo, Nigeria.
Ngozi Paulinus Okolie: Department of Biochemistry, University of Benin, Nigeria.
Gerald Ikechi Eze: Department of Anatomy, University of Benin, Nigeria.
Samson Adewale Oyebadejo: Department of Anatomy, University of Uyo, Uyo, Nigeria.

Journal of Asian Scientific Research, 2019, vol. 9, issue 8, 81-94

Abstract: Arsenic is a known environmental pollutant that is detrimental to health. In this study, the effect of ethanol stem bark extract of Irvingia gabonensis (ESEIG) against sodium arsenite-induced hepatotoxicity in Wistar rats was investigated. Wistar albino rats of weights between 100 and 179g were assigned to eleven (11) groups of five (5) animals each. Group 1 (control) was given feed and water ad libitum. Group 2 was exposed to sodium arsenite (SA) at a dose of 4.1 mg/kg body weight (kgbw) for two weeks. Groups 3-11 were treated with ESEIG with or without SA. Treatment was done orally and lasted 28 days. Serum activities of AST, ALT, ALP, GGT as well as total bilirubin, (TBIL) and direct bilirubin, (DBIL) concentrations were assayed in serum in addition to histological assessment of liver tissues. Exposure to SA caused significant (p˂0.05) increases in all assayed parameters as well as histological anomalies such as vascular congestion and ulceration, infiltration of inflammatory cells and Kupffer cell activation when compared with control. However, treatment with ESEIG both simultaneously and 2 weeks after SA exposure, reversed the deleterious effects of SA. Paradoxically, administration of the ESEIG alone at different doses produced significant (p˂0.05) increases in all assayed parameters when compared with control except TBIL. The results obtained in this study suggest that ESEIG may be protective against SA-induced hepatotoxicity in Wistar rats and slightly toxic when administered alone, necessitating further studies.

Keywords: Arsenic; sodium arsenite; Irvingia gabonensis; Hepatotoxicity; Environmental pollutant; Medicinal plants; Bush mango; Histology. (search for similar items in EconPapers)
Date: 2019
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