Distinctive roles of left and right entorhinal cortex in path integration via a non-invasive stimulation study

Haiyan Zhao, Binglei Zhao (), Jiajun He and Manhua Liu ()
Additional contact information
Haiyan Zhao: Shanghai Jiao Tong University, MoE Key Lab of Artificial Intelligence, AI Institute
Binglei Zhao: Shanghai Jiao Tong University, School of Psychology
Jiajun He: Johns Hopkins University, Biomedical Engineering Department
Manhua Liu: Shanghai Jiao Tong University, MoE Key Lab of Artificial Intelligence, AI Institute

Nature Communications, 2025, vol. 16, issue 1, 1-15

Abstract: Abstract The entorhinal cortex (EC) is known to play important roles in spatial cognition of human behaviors. However, the functional contributions and the lateralization of EC are not well known. This paper proposed a new paradigm by employing non-invasive stimulation - Temporal interference (TI) - of human EC in left or right hemisphere under path integration (PI) tasks of sensory-driven and abstract processing. Five metrics were introduced to evaluate PI performance, with results revealing significant improvements after EC stimulation. Moreover, the left EC modulation achieved more enhanced performances of abstract processing, whereas the modulation of the right EC had better improvements in the sensory-driven condition. The results indicated that functional roles may differ in left and right EC under PI tasks. This study provided valuable insights into hemispheric specialization within EC and suggested potential pathways for developing early intervention strategies through the non-invasive modulation of EC.

Date: 2025
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-025-64986-8 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-64986-8

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-025-64986-8

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().