MicroRNA-mediated metabolic disruption as an emerging driver of alcohol use disorder

Colin J. McArdle and Kimberly F. Raab-Graham ()
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Colin J. McArdle: Wake Forest University School of Medicine
Kimberly F. Raab-Graham: Wake Forest University School of Medicine

Nature Communications, 2025, vol. 16, issue 1, 1-3

Abstract: Previous research has sought to determine the underlying mechanisms that govern the development of Alcohol Use Disorder (AUD). In a recent study by Ehinger et al., excessive alcohol consumption utilizes mTORC1’s under characterized role in repressing mRNA translation through the upregulation of microRNAs, specifically in a D1-circuit-specific manner, resulting in repression of glycolysis in the brain’s reward pathway.

Date: 2025
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DOI: 10.1038/s41467-025-65743-7

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