PLOS Clinical Trials

2006 - 2007

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Development and Evaluation of a Pedagogical Tool to Improve Understanding of a Quality Checklist: A Randomised Controlled Trial pp. 1-8: Lola Fourcade, Isabelle Boutron, David Moher, Lucie Ronceray, Gabriel Baron and Philippe Ravaud
Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial pp. 1-9: Moses R Kamya, Adoke Yeka, Hasifa Bukirwa, Myers Lugemwa, John B Rwakimari, Sarah G Staedke, Ambrose O Talisuna, Bryan Greenhouse, François Nosten, Philip J Rosenthal, Fred Wabwire-Mangen and Grant Dorsey

A Randomized, Double-Blind, Placebo-Controlled Trial of Lessertia frutescens in Healthy Adults pp. 1-7: Quinton Johnson, James Syce, Haylene Nell, Kevin Rudeen and William R Folk
When and How Can Endpoints Be Changed after Initiation of a Randomized Clinical Trial pp. 1-3: Scott Evans

Quality of Life in HIV Clinical Trials: Why Sexual Health Must Not Be Ignored pp. 1-1: Olivier Koole, Christiana Noestlinger and Robert Colebunders
Factors in AIDS Dementia Complex Trial Design: Results and Lessons from the Abacavir Trial pp. 1-10: Bruce J Brew, Mark Halman, Jose Catalan, Ned Sacktor, Richard W Price, Steve Brown, Hamp Atkinson, David B Clifford, David Simpson, Gabriel Torres, Colin Hall, Christopher Power, Karen Marder, Justin C Mc Arthur, William Symonds and Carmen Romero
Short-Term Efficacy of Rofecoxib and Diclofenac in Acute Shoulder Pain: A Placebo-Controlled Randomized Trial pp. 1-9: Maxime Dougados, Anne Le Henanff, Isabelle Logeart and Philippe Ravaud

Phase III Trial of Albumin in Malaria Still Lacks Scientific Justification pp. 1-2: Charles J Woodrow and Timothy Planche
Inadequate Evidence to Support Phase III Studies of Albumin in Severe Malaria pp. 1-2: Charles J Woodrow and Timothy Planche

Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda pp. 1-8: Gerardo Priotto, Carole Fogg, Manica Balasegaram, Olema Erphas, Albino Louga, Francesco Checchi, Salah Ghabri and Patrice Piola

Safety and Allele-Specific Immunogenicity of a Malaria Vaccine in Malian Adults: Results of a Phase I Randomized Trial pp. 1-8: Mahamadou A Thera, Ogobara K Doumbo, Drissa Coulibaly, Dapa A Diallo, Issaka Sagara, Alassane Dicko, David J Diemert, D Gray Heppner, V Ann Stewart, Evelina Angov, Lorraine Soisson, Amanda Leach, Kathryn Tucker, Kirsten E Lyke, Christopher V Plowe and for the Mali FMP1 Working Group
Cardiovascular and Cerebrovascular Events in the Randomized, Controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT) pp. 1-10: Research Group Adapt

Publishing Clinical Trial Results: The Future Beckons pp. 1-4: Elizabeth Wager

Three Steps to Protecting Pediatric Research Participants from Excessive Risks pp. 1-5: David Wendler
Volume Expansion with Albumin Compared to Gelofusine in Children with Severe Malaria: Results of a Controlled Trial pp. 1-11: Samuel Akech, Samson Gwer, Richard Idro, Greg Fegan, Alice C Eziefula, Charles R J C Newton, Michael Levin and Kathryn Maitland

The Influence of Injection Rate on the Hypnotic Effect of Propofol during Anesthesia: A Randomized Trial pp. 1-7: Jasmin Blum, Eberhard Kochs, Nicole Forster and Gerhard Schneider

The Clinical Trials Directive: How Is It Affecting Europe's Noncommercial Research pp. 1-5: Markus Hartmann and Florence Hartmann-Vareilles

Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly People: The LOTIS Trial pp. 1-6: Anton J M de Craen, Jacobijn Gussekloo, Gerard J Blauw, Charles G Willems and Rudi G J Westendorp
Principles for Strengthening the Integrity of Clinical Research pp. 1-4: David Korn and Susan Ehringhaus
Introducing PLoS Clinical Trials pp. 1-1: Emma Veitch
Patient Safety Requires a New Way to Publish Clinical Trials pp. 1-3: Richard Smith and Ian Roberts
Factors That Can Affect the External Validity of Randomised Controlled Trials pp. 1-5: Peter M Rothwell