The unsuspected "bodyguards" of red blood cells

Gianluigi Zangari del Balzo

No k2ubf, OSF Preprints from Center for Open Science

Abstract: Transferrin is the main intrabody carrier of iron. An in-depth analysis of the struc- ture, conformation distribution and functions of this protein allowed us to predict its unsuspected “non-canonical” function in the metabolism of mature red blood cells. In this work we propose a theory of the energy landscape with static and dynamic macro- molecular simulations, performed with an unconventional statistical calculus, which analyze the conformation transformations of Transferrin from a closed to an open and activated structure (“open jaws”) during the follow-up of mature red blood cells. The result is a finite set of N states of low entropy, of which a subset N-p corresponds to conformations of minimum entropy where Transferrin binds to a specialized receptor, surviving in mature red blood cells.

Date: 2020-08-14
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Persistent link: https://EconPapers.repec.org/RePEc:osf:osfxxx:k2ubf

DOI: 10.31219/osf.io/k2ubf

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