Soluble FMS-like tyrosine kinase-1/Pro- angiogenic placental growth factor (sFlt- 1/PlGF) ratio as an early predictor for oxygenation impairment in preeclampsia

Anindya Arianditha Ardani (), Mariza Fitriati (), Prananda Surya Airlangga (), Lila Tri Harjana () and Manggala Pasca Wardhana ()

International Journal of Innovative Research and Scientific Studies, 2025, vol. 8, issue 4, 1370-1375

Abstract: Preeclampsia is a major cause of maternal mortality worldwide, with angiogenic imbalance playing a central role in its pathophysiology. This study aimed to investigate the relationship between the soluble fms-like tyrosine kinase-1 to placental growth factor (sFlt-1/PlGF) ratio and oxygenation impairment in preeclamptic patients. A cross-sectional observational study was conducted on 47 women with singleton pregnancies diagnosed with preeclampsia at a gestational age beyond 34 weeks who underwent cesarean delivery. Data were obtained from medical records, including sFlt-1 and PlGF serum levels, sFlt-1/PlGF ratio, and arterial blood gas analysis for calculating PaO₂/FiO₂ (P/F) ratios. A significant negative correlation was found between the sFlt-1/PlGF ratio and the P/F ratio (r = -0.514, p < 0.001), indicating that a higher angiogenic imbalance is associated with poorer oxygenation status. Receiver operating characteristic (ROC) curve analysis revealed a cut-off value of 138.58 for the sFlt-1/PlGF ratio, with 83.33% sensitivity and 80% specificity for predicting oxygenation impairment. These findings suggest that the sFlt-1/PlGF ratio may serve as an early biomarker for detecting oxygenation disturbances in preeclampsia, supporting timely clinical interventions.

Keywords: Angiogenesis inhibitors; Biomarkers; Endothelial dysfunction; Pregnancy complications; Respiratory insufficiency. (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:aac:ijirss:v:8:y:2025:i:4:p:1370-1375:id:8077

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