Anti-phospholipid antibodies and osteopontin in young adults with cerebrovascular stroke

Eman Abbas Alkady (), Zahraa Ibrahim Abou-Eloyoun (), Samar Hassanein Goma (), Sally Samir Hussein () and Ahmed Nasr Eldein Hendy ()

International Journal of Innovative Research and Scientific Studies, 2025, vol. 8, issue 5, 1631-1644

Abstract: To estimate the frequency of antiphospholipid syndrome (APS) in young adults with cerebrovascular events (CVE), assess whether aPLA-positive individuals have a higher risk of ischemic stroke than aPLA-negative individuals, and evaluate the correlation between osteopontin (OPN) levels, aPLA, and cerebrovascular stroke (CVS). This prospective randomized controlled study was conducted on 72 patients aged less than 50 years, of both sexes, with cerebrovascular events (CVE) (Group I) and 40 apparently healthy individuals as controls (Group II). There was a significant correlation between the level of osteopontin (OPN) and anticardiolipin immunoglobulin G (ACL IgG) (P= 0.012). OPN, baseline ACL IgM, ACL IgG, lupus anticoagulant (LA1), LA1/LA2 ratio, and anti-β2 glycoprotein (GPI) IgG were significantly higher in the case group than in the control group (P<0.05). ROC curves for diagnosis of CVS in young adults by OPN, at a cut off ≥ 45, sensitivity 72.2%, specificity 68.7% and P<0.001. The study documented the increased incidence of APS as an etiology of CVE in young adults. Osteopontin markers might be sensitive and specific for the diagnosis of CVE in young adults. Early screening for APS and osteopontin levels in young adults presenting with CVE may enable earlier diagnosis, targeted treatment, and potentially improved prevention of recurrent strokes.

Keywords: Anti-phospholipid antibodies; Cerebrovascular stroke; Osteopontin; Young adults. (search for similar items in EconPapers)
Date: 2025
References: Add references at CitEc
Citations:

Downloads: (external link)
https://ijirss.com/index.php/ijirss/article/view/9206/2067 (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:aac:ijirss:v:8:y:2025:i:5:p:1631-1644:id:9206

Access Statistics for this article

International Journal of Innovative Research and Scientific Studies is currently edited by Natalie Jean

More articles in International Journal of Innovative Research and Scientific Studies from Innovative Research Publishing
Bibliographic data for series maintained by Natalie Jean ().