INVESTIGATIONS OF THE INFLUENCE OF SUFAN ON MYOCARDIAL METABOLISM IN CASES OF EXPERIMENTAL HEART FAILURE

Iryna Nizhenkovskaya ()
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Iryna Nizhenkovskaya: Bogomolets National Medical University, Kiev, Ukraine

CBU International Conference Proceedings, 2014, vol. 2, issue 0, 313-318

Abstract: This article presents the results of an influence by the new non-glycoside structure, metabolic cardiotonic drug “sufan” on the energetic metabolism and oxidative homeostasis indicators—in myocardium, brain, and spleen of intact rats and rats with adriamycin-induced heart failure. It was established that sufan increased the coefficient of oxidative/reduced forms of nicotinamide coenzymes, reduced the adriamycin, causing deterioration of the energetic metabolism and the pro-oxidative-anti-oxidative homeostasis. The use of the non-glycoside structure cardiotonic drug, sufan, is recommended in order to prevent cardiotoxic effects of the anthracycline antibiotics.

Keywords: sufanadriamycin hydrochloride; heart failure; energetic metabolism (search for similar items in EconPapers)
Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:aad:iseicj:v:2:y:2014:i:0:p:313-318

DOI: 10.12955/cbup.v2.477

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