IMPACT OF CAROTID ENDARTERECTOMY ON COGNITIVE PERFORMANCE AND DEPRESSIVE SYMPTOMS

Elina Pucite (), Marius Slisers (), Evija Miglane (), Dainis Krievins (), Renars Erts (), Kristaps Jurjans () and Ildze Krievina ()
Additional contact information
Elina Pucite: Pauls Stradins Clinical University Hospital
Marius Slisers: University of Latvia
Evija Miglane: Pauls Stradins Clinical University Hospital
Dainis Krievins: Pauls Stradins Clinical University Hospital
Renars Erts: Pauls Stradins Clinical University Hospital
Kristaps Jurjans: Pauls Stradins Clinical University Hospital
Ildze Krievina: Pauls Stradins Clinical University Hospital

CBU International Conference Proceedings, 2016, vol. 4, issue 0, 608-614

Abstract: OBJECTIVES: This study aims to evaluate the impact of carotid endarterectomy (CEA) on cognitive performance in patients with severe carotid disease and depressive symptoms, and to explore the possible associations between certain demographics, clinical characteristics, and cognitive function and depression.MATERIALS AND METHODS: The study included 48 patients, who were referred for endarterectomy. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA) scale, while depressive symptoms were assessed using the patient health questionnaire(PHQ-9) scale. An assessment of cognitive and depressive symptoms was performed 1–3 days before surgery, and then six months after.RESULTS: A paired sample t-test found that the difference in the mean MoCA score between the before ( =23.37; SD ± 3.27) and the after ( =24.69; SD ± 3.68) surgery results was 1.32 (95% CI = 0.48 – 2.16; p= 0.003; Cohen’s d value = 0.95). A paired sample t-test showed that a decrease in mean PHQ-9 score of > 10 for patients six months after CEA (7.5±4.6) was statistically significant (p= 0.019; Cohen’s d value = 1.32) compared with the PHQ-9 scores at baseline (12.6 ± 2.8).CONCLUSION: Carotid artery endarterectomy seems to have beneficial effects on the course of cognitive impairment and depressive symptoms in patients with severe carotid artery stenosis. Demographic, clinical characteristics (age, gender, comorbidities, previous stroke) did not have impact on course of cognitive and depressive symptoms. A limitation in our study was that the number of patients was relatively small, therefore we intend to perform further study with larger case volume to estimate the impact of carotid artery endarterectomy on cognitive functions and depressive symptoms.

Keywords: carotid endarterectomycognitive impairment; depressive symptoms (search for similar items in EconPapers)
Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:aad:iseicj:v:4:y:2016:i:0:p:608-614

DOI: 10.12955/cbup.v4.820

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