STABILITY EVALUATION OF CAFFEINE-8-THIOGLICOLIC ACID AMIDES, WITH DETERMINED ANTIHYPOXIC EFFECTS

Javor Mitkov (), Maya Georgieva () and Alexander Zlatkov ()
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Javor Mitkov: Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria
Maya Georgieva: Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria
Alexander Zlatkov: Medical University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 2 Dunav Street, 1000 Sofia, Bulgaria

CBU International Conference Proceedings, 2017, vol. 5, issue 0, 1266-1274

Abstract: This study evaluates a series of caffeine-8-thioglycolic acid amides that were synthesized in the study, for signs of possible degradation. The chemical stability of the test compounds was examined under different conditions of pH and temperature over time. A modified reversed phase-high-performance liquid chromatography method was applied to determine stability and identify possible degradation products. The study identified a new product from oxidative destruction of the test compound through controlled synthesis.

Keywords: caffeine-8-thioglycolic acid amidesstability; RP-HPLC (search for similar items in EconPapers)
Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:aad:iseicj:v:5:y:2017:i:0:p:1266-1274

DOI: 10.12955/cbup.v5.1107

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