Leprosy Overview: Pathophysiology, Immune Responses, and Epidemiology in Brazil

Manuela B Pucca
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Manuela B Pucca: Health Sciences Postgraduate Program, Federal University of Roraima, Brazil

Biomedical Journal of Scientific & Technical Research, 2023, vol. 48, issue 4, 39867-39875

Abstract: Leprosy is an infectious disease caused by a parasite, known as Mycobacterium leprae, able to infect cells from peripheral nerves, leading to a high disabling power due to neural impairment. This pathology is common in more than 120 countries, with more than 100,000 cases occurring every year. Both innate and acquired immune responses are involved, but the disease has been classically described along a Th1/Th2 spectrum, where the Th1 pole corresponds to the most limited presentations and the Th2 to the most disseminated ones. Due to the clinical and histopathological diversity of the disease, the immunopathogenesis of leprosy is not completely understood. Our review describes the role of the immune system in the pathogenesis of leprosy aiming to understand the mechanisms involved in the development of the different immune responses against the disease.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:48:y:2023:i:4:p:39867-39875

DOI: 10.26717/BJSTR.2023.48.007676

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