Cytomorphology of Human Bone Marrow Subjected to Prolonged Standing That Mimic Changes Similar to One Observed in Myelodysplastic Syndromes

Anwarul Islam
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Anwarul Islam: M.D., Ph.D., FRCPath., FACP, Clinical Associate Professor of Medicine, State University of New York at Buffalo, Attending Physician Division of Hematology, Oncology Department of Medicine, Buffalo General Medical Center, Buffalo, New York, USA

Biomedical Journal of Scientific & Technical Research, 2023, vol. 49, issue 1, 40268-40273

Abstract: Bone marrow aspiration is an invaluable tool in the characterization of various clinical conditions and is extensively used in hematology and oncology. Conventionally, it involves the cytology of bone marrow cells smeared on a slide, their subsequent staining with a Romanowsky stain, and their careful examination under a bright field microscopy. We have studied freshly prepared bone marrow aspirate smears and compared them with smears made from a sample (obtained at same time and standing at room temperature) at regular intervals up to 24 hours post-aspiration. Our study demonstrates that prolonged standing causes morphologic changes that mimic specific features of myelodysplasia and may interfere with accurate interpretation and diagnosis.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:49:y:2023:i:1:p:40268-40273

DOI: 10.26717/BJSTR.2023.49.007740

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