Impairing Dopaminergic Cells in Olfactory Bulb Decreases Number of the Dopaminergic Cells in Substantial Nigra of Rats

Irami Araújo-FilhoYan Huang, Haichen Niu and Deqin Geng
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Deqin Geng: Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, 221006, PR China

Biomedical Journal of Scientific & Technical Research, 2023, vol. 49, issue 2, 40429-40436

Abstract: Parkinson disease (PD) is a neurodegenerative disorder characterized by the massive loss of midbrain dopaminergic neurons with the motor impairments. However, a popular of hyposmia and olfactory dysfunction are found before the onset of motor impairments. It’s known that the olfactory system is the only organ that can directly contact with the environment, which is easily affected by environmental toxin than other organs. However, it’s unclear that damaging olfaction can induce the pathological response of the dopaminergic cells in the nigrostriatal system resulting in the impairment of motor.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:49:y:2023:i:2:p:40429-40436

DOI: 10.26717/BJSTR.2023.49.007771

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