Synthesis, and Biological Investigation of Bis [N-(4-Pyridyl) Sulfonamide] Dichloride Palladium: MEP, and Molecular Docking as an Antibacterial and an Anticancer Agents

Parvaneh Shafieyoona
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Parvaneh Shafieyoona: Department of Chemistry, Faculty of Science, Lorestan University, Iran

Biomedical Journal of Scientific & Technical Research, 2023, vol. 49, issue 2, 40470-40476

Abstract: In the present work, the compound (N-(4-pyridyl-p-toluene sulfonamide) as a ligand was prepared from the reaction of 4-aminopyridine and p-toluene sulfonyl chloride in presence of one molar potassium hydroxide solution as a base and tetrahydrofuran as a solvent. Palladium dichloride was used for the synthesis of [bis (N-(4-pyridyl-p-toluene sulfonamide)] complex. The structure of the synthesized compounds was confirmed by FTIR. Elemental analysis of palladium by Inductively Coupled Plasma (ICP) and hot loading filtration test. MEP (Molecular Electrostatic Potential) of ligand and molecular docking ligand and pd complex was performed. This research indicated ligand of sulfonamide was Biocompatible and has an antibacterial property and its pd complex is an anticancer agent.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:49:y:2023:i:2:p:40470-40476

DOI: 10.26717/BJSTR.2023.49.007776

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