Investigation of a Novel Biocompatible Fast-Gelling Hydrogel for Neurodegenerative Diseases

Song Jiang
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Song Jiang: Department of Biochemistry, Huzhou Institute Of Biological Products Co., Ltd. China

Biomedical Journal of Scientific & Technical Research, 2023, vol. 50, issue 3, 41647-41653

Abstract: A novel biocompatible fast-gelling hydrogel has been explored for neurodegenerative diseases. The hydrogel is formed using thiol-maleimide reaction. The precursors maleimide modified 4-arm polyethylene glycol (PEG) and thiolated hyaluronic acid (HA) were created and characterized by NMR. The hydrogel was investigated by the measurement of gelation time, swelling ratio, viscoelasticity and degradation. Based on the data of gelation time, we found that the hydrogel with two percent maleimide modified 4-arm PEG and thiolated HA was most appropriate for tuning. This percentage of hydrogel was selected for other tests. The tests of swelling ratio and degradation indicated hydrogel was flexible and degradable. The viscoelasticity test revealed that the hydrogel is an elastic solid. From these measurements, this novel biocompatible fastgelling hydrogel could be used for the treatment of neurodegenerative diseases.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:50:y:2023:i:3:p:41647-41653

DOI: 10.26717/BJSTR.2023.50.007951

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