Inhibitory Effect of Magnolol on Activation of EGFR L858R/T790M/G796R

Pei-Yuan Sun and Jing Wang
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Jing Wang: Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, China

Biomedical Journal of Scientific & Technical Research, 2023, vol. 50, issue 3, 41660-41666

Abstract: Epidermal growth factor receptor (EGFR)-activating mutations are critical factors in EGFR-driven nonsmall cell lung cancer (NSCLC) development, and molecular targeted therapies have focused on inhibiting these mutations. EGFR tyrosine kinase inhibitors (TKIs) have remarkable inhibitory effect for NSCLC with EGFR mutations. However, acquired resistance limited the clinical application of EGFR-TKIs, which highlights the need for discovery of novel inhibitors. In this study, we created Ba/F3 cells harboring EGFR L858R/T790M/G796R mutations, and then found magnolol effectively inhibited EGFR L858R/T790M/ C797S activation, which may be a potential strategy against osimertinib-resistant EGFR mutations.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:50:y:2023:i:3:p:41660-41666

DOI: 10.26717/BJSTR.2023.50.007953

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