Risk Factors, Biomarkers, Molecular and Cellular Mechanisms of Vascular Calcification Genesis and its Methods of Detection

Leta Melaku
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Leta Melaku: Assistant Professor of Medical Physiology, Department of Biomedical Sciences, College of Health Sciences, Arsi University, Ethiopia

Biomedical Journal of Scientific & Technical Research, 2023, vol. 50, issue 4, 41839-41859

Abstract: Vascular calcification has traditionally been a passive process. However, in the last years, it has been proven to be an actively regulated biological process that is associated with crystallization of hydroxyapatite in the extracellular matrix and in cells of the media (VCm) or intima (VCi) of the arterial wall. Corresponding to bone mineralization, different pro and anti-calcifying mechanisms play an active role in mineral deposition in vascular cells. Evidence from clinical observations, animal models, and molecular studies suggest factors that regulate bone cell differentiation and mineralization, including fetuin A, BMP-2, matrix gla protein, osteopontin, osteoprotegerin, and inorganic pyrophosphate are used as biomarkers of vascular calcification.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:50:y:2023:i:4:p:41839-41859

DOI: 10.26717/BJSTR.2023.50.007982

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