Activated Translation of HIF-1α mRNA as a Key Mechanism in Oncogenesis of Pancreatic Ductal Adenocarcinoma and Other Malignant Diseases

Mitsuru Sakitani
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Mitsuru Sakitani: Director of the Institute CCC, Ibukidai-Higashimachi, Nishi ward, Kobe, Hyogo, Japan

Biomedical Journal of Scientific & Technical Research, 2023, vol. 51, issue 5, 43069-43072

Abstract: Molecular targeted therapies against KRAS mutant pancreatic ductal adenocarcinoma (PDAC) remain insufficient. The most serious causes are supposed to be bypass activation of the PI3K/AKT/mTOR signaling pathway and crosstalk between mTOR and hypoxia inducible factor (HIF). This short review is aimed at clarifying the involvement of activated translation of HIF-1α mRNA in oncogenesis of KRAS mutant PDAC in association with CA9 activation.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:51:y:2023:i:5:p:43069-43072

DOI: 10.26717/BJSTR.2023.51.008156

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