Cytokine-Induced Neurogenesis and Gut Microbiota in Alzheimer’s Disease

Takuji Shirasawa
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Takuji Shirasawa: Ochanomizu Health and Longevity Clinic, Tokyo 101-0062, Japan

Biomedical Journal of Scientific & Technical Research, 2023, vol. 51, issue 5, 43080-43088

Abstract: Alzheimer’s Disease (AD) is a progressive neurodegenerative disease for which no curative treatment has yet been established. We applied cytokine-induced neurogenesis treatment to a 73-year-old female AD patient carrying APOE ε4/ε4 alleles to regenerate residual neuronal stem cells, resulting in the successful regeneration of the atrophied hippocampus, which was associated with improved cognitive functions and the resolution of electrophysiological abnormalities. We also investigated the gut microbiota to clarify the modifiers that influence the progression of AD. Microbiota analysis showed the specific dysbiosis signature of Mild Cognitive Impairment (MCI), but this patient had milder dysbiosis than other MCI patients, which may modify the progression of AD pathology.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:51:y:2023:i:5:p:43080-43088

DOI: 10.26717/BJSTR.2023.51.008159

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