The Effects of Growth Disorder-Related Mutations on The Conformational Structure of Insulin-like Growth Factor (IGF1)- An In Silico Study

Muhammad Adnan Shah Bukhari
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Muhammad Adnan Shah Bukhari: Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan

Biomedical Journal of Scientific & Technical Research, 2023, vol. 52, issue 3, 43786-43793

Abstract: Insulin-like Growth Factor-1 (IGF1) is a hormone that plays a vital role in human growth and development. It regulates cell proliferation and tissue growth. Any alterations in the structure or function of IGF1 can have profound implications for various functions and diseases, including cancer and growth disorders. In this study, a comprehensive computational analysis was performed to examine the impact of single amino acid substitutions on IGF1 tertiary structure. The study involved using In Silico tools for comparing the amino acid sequences of wild-type and three variant IGF1 proteins, as well as assessing their physicochemical properties.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:52:y:2023:i:3:p:43786-43793

DOI: 10.26717/BJSTR.2023.52.008263

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