Research on the Molecular Mechanism of Combination Triptolide with Dexamethasone in Treatment of Rheumatoid Arthritis based on Bioinformatics Analysis

Lianbo Xiao
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Lianbo Xiao: Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine, China

Biomedical Journal of Scientific & Technical Research, 2023, vol. 53, issue 1, 44207-44216

Abstract: Triptolide (TP), a diterpenoid triepoxide from Tripterygium wilfordii Hook F, can ameliorate rheumatoid arthritis (RA) through multiple molecular mechanisms. However, serious side effects limit its clinic application. Previous studies have shown that combination of TP with dexamethasone (DXM) had the synergetic effect, but the mechanism is still unknown. Therefore, this study aims to investigate the molecular mechanism of combination TP with DXM in the treatment of rheumatoid arthritis by bioinformatics analysis.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:53:y:2023:i:1:p:44207-44216

DOI: 10.26717/BJSTR.2023.53.008331

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