Clinical Pharmacology of Imipenem/Cilastatin

Gian Maria Pacifici
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Gian Maria Pacifici: Professor of Pharmacology, via Sant’Andrea 32, 56127 Pisa, Italy

Biomedical Journal of Scientific & Technical Research, 2023, vol. 53, issue 3, 44636-44648

Abstract: Imipenem is a β-lactam antibiotic and is market in combination with cilastatin a drug that inhibits the degradation of imipenem by renal tubular dipeptidase and extends the elimination half-life of imipenem. Imipenem binds to penicillin-binding proteins, disrupts bacterial cell wall synthesis, and causes depth of susceptible organisms. Imipenem is resistant to hydrolysis by most β-lactamases and is active against a wide variety of aerobic and anaerobic microorganisms. Streptococci (including penicillinase-resistant Streptococcus pneumoniae), Enterococcus faecalis, staphylococci (including penicillinase-producing strains but not methicillin-resistant Staphylococcus aureus).

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:53:y:2023:i:3:p:44636-44648

DOI: 10.26717/BJSTR.2023.53.008393

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