Clinical Utility of Individualized Follow-Up in Acute Myeloid Leukemia (AML) Patients Using a Myeloid NGS Panel

Marta Fernández Mercado
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Marta Fernández Mercado: Hematological Diseases Laboratory, CIMA LAB Diagnostics, University of Navarra, Spain

Biomedical Journal of Scientific & Technical Research, 2023, vol. 53, issue 3, 44727-44741

Abstract: The current standard to determine complete remission in acute myeloid leukemia (AML) includes morphologic criteria, cytogenetics, classical molecular analysis -such as polymerase chain reaction (PCR) and quantitative reverse-transcription PCR (RT-qPCR), and flow cytometry. Recently, NextGeneration Sequencing (NGS) is being a useful tool to gain insights into the molecular alterations in patients diagnosed with AML. We hypothesized that deeper knowledge of the clonal dynamics of AML could potentially be of clinical utility. We studied with our custom Pan-Myeloid NGS Panel the genomic alterations of 71 samples, corresponding to 20 AML cases during disease follow-up. Sequencing data identified genomic clonal markers with clinical utility in 90% of cases.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:53:y:2023:i:3:p:44727-44741

DOI: 10.26717/BJSTR.2023.53.008401

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