Axonal Transport Blockade in Abusive Head Trauma Suspects; A Mini Review

Don Minckler
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Don Minckler: Recall Professor for Teaching, University of California Irvine, Emeritus Professor of Ophthalmology and Laboratory Medicine, USA

Biomedical Journal of Scientific & Technical Research, 2023, vol. 54, issue 1, 45475-45476

Abstract: This report summarizes the application of Amyloid Beta Protein (APP-A4) immunohistochemistry to the study of ocular tissues from victims of suspected child abuse, aka Abusive Head Trauma (AHT). The two referenced publications summarize the history of AHT, its confusing terminology and tortured medico-legal issues. Additionally, they describe the ocular histopathology and Immunohistochemistry (IHC) utilizing (APP-A4), the only available antibody for human tissue analysis of orthograde axonal transport. The two publications include findings from 76 autopsied cases of suspected child abuse concentrating on retinal and optic nerve findings, especially the Lamina Cribrosa (LC) portion of the optic nerve. The first paper published discussed five cases judged to have unusual IHC findings, compared to prior personal experience [1].

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:54:y:2023:i:1:p:45475-45476

DOI: 10.26717/BJSTR.2023.54.008503

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