Transcriptomic Profiling Reveals the Underlying Mechanism of Interferon-Epsilon (IFN-ε) and InterferonGamma (IFN-γ) Combination in Cervical Cancer

Siew Woh Choo
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Siew Woh Choo: Department of Biology, College of Science, Mathematics and Technology, Wenzhou-Kean University, China

Biomedical Journal of Scientific & Technical Research, 2023, vol. 54, issue 1, 45510-45662

Abstract: Cervical cancer remains a global health challenge, with its treatment necessitating novel therapeutic strategies. This study delves into the synergistic effects of interferons IFN-ε and IFN-γ on cervical cancer using high-throughput sequencing technology, specifically targeting the HaLa S3 cell line. Our cell viability assays demonstrate that the combination of IFN-ε and IFN-γ exerts a substantial inhibitory effect on these cells. Transcriptomic analysis revealed a total of 6,265 differentially expressed genes (DEGs) were identified in cells treated by IFN-ε and IFN-γ, including 3,363 significantly up-regulated DEGs and 2,902 significantly down-regulated DEGs. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses suggest that the up-regulated DEGs mainly enriched in immune response.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2023
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:54:y:2023:i:1:p:45510-45662

DOI: 10.26717/BJSTR.2023.54.008510

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