Case Series of Ceftriaxone-Induced Neutropenia and Leukopenia- Experience in Outpatient Parenteral Antimicrobial Therapy (OPAT) Setting

Sue Wen Leo, Isabel Sze Wing Fok, Swapna R Motukupally, Karen Fan and Freeman Wu
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Sue Wen Leo: Antimicrobial and High Cost Drugs Pharmacist, Co-lead of OPAT Service at United Lincolnshire Hospitals NHS Trust, UK
Isabel Sze Wing Fok: Specialist Clinical Pharmacist – Intestinal Failure, Nottingham University Hospitals NHS Trust, UK
Swapna R Motukupally: Locum Consultant Microbiologist, Pathlinks, North Lincolnshire & Goole NHS Foundation Trust, United Lincolnshire Hospitals NHS Trust, UK
Karen Fan: Antimicrobial Admin Support at United Lincolnshire Hospitals NHS Trust, UK
Freeman Wu: Antimicrobials and OPAT Operational Lead Pharmacist, United Lincolnshire Hospitals NHS Trust, UK

Biomedical Journal of Scientific & Technical Research, 2024, vol. 54, issue 4, 46202-46208

Abstract: Ceftriaxone is a commonly used antibiotic to treat a range of infections, particularly for central nervous system, skin and soft tissues as well as bone and joint infections. The course length of ceftriaxone for these indications can range between 2 to 6 weeks in both hospital and outpatient parenteral antimicrobial therapy (OPAT) settings. With prolonged courses being used, coupled with the general understanding that beta-lactam antibiotics are safer than other classes of antibiotics, there is a need for increasing awareness of safety of ceftriaxone, particularly on rarer but more serious adverse effects, such as neutropenia and leukopenia, which may lead to clinical complications.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:54:y:2024:i:4:p:46202-46208

DOI: 10.26717/BJSTR.2024.54.008591

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