Prognostic Value of Proliferation Markers Ki-67 and p53 in Patients with Recurrent Macro- and Giant NonFunctional Pituitary Tumors

Mirtukhtaeva Mb, Khudaybergenov Sh A, Saydakhmedova Mu, Urmanova Yu M and Alieva Da
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Mirtukhtaeva Mb: Endocrinologist of the Department of Neuroendocrinology with Pituitary Surgery RSNPMCE Ministry of Health of the Republic of Uzbekistannamed after academician Y.H. Turakulova, Uzbekistan
Khudaybergenov Sh A: Doctor of Medical Sciences, Professor of the Department of Endocrinology, Pediatric Endocrinology Tash PMI, Uzbekistan
Saydakhmedova Mu: Head of the Department of Physiotherapy, RSNPMCE, Ministry of Health of the Republic of Uzbekistannamed after academician Y.H. Turakulova, Uzbekistan
Urmanova Yu M: Department of Surgical Diseases, TashPMI, Uzbekistan
Alieva Da: 3rd year Master of Study at TashPMI, Department of Endocrinology, Pediatric Endocrinology, Tash PMI, Uzbekistan

Biomedical Journal of Scientific & Technical Research, 2024, vol. 54, issue 5, 46470-46473

Abstract: Non-functional pituitary adenomas (NFPA) are the most common type of pituitary macroadenomas, accounting for 25–35% of all cases [1]. They are usually benign, but many infiltrate the sphenoid sinus, cavernous sinus, or dura mater and cannot be completely removed by surgical resection. Because residual cells retain the ability to proliferate, residual tumors may re-proliferate, requiring new therapeutic interventions [2]. Most relapses occur within five years after surgery. Due to the high rate of distant relapses, the prognosis for patients is not always favorable: surgery is the main treatment for NFPA, and there is currently no effective pharmacological treatment for NFPA [3,4].

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:54:y:2024:i:5:p:46470-46473

DOI: 10.26717/BJSTR.2024.54.008623

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