PAI mutation 4G/5G- Coagulopathy Risk Factor for Stroke or Multiple Sclerosis

Maria Cholakova, Nikolay Mihnev and Ivan Staikov
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Ivan Staikov: Clinic of Neurology, Acibadem City Clinic Tokuda University Hospital, Bulgaria

Biomedical Journal of Scientific & Technical Research, 2024, vol. 55, issue 1, 46516-46519

Abstract: Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) with difficult differential diagnosis. The new trials show the importance of PAI-1 in etiology of neuroinflammation and neurodegeneration in multiple sclerosis. PAI mutation of 4G/5G is a risk factor for thrombotic events in young adults. We present a prospective study with patient diagnosed with MS and examined for thrombophilia, especially PAI mutation 4G/5G. Observational study was performed to evaluate the incidence of PAI mutation in patients with ischemic stroke and healthy control group. A comparison analyses was done in the three groups of patients. PAI mutation could play a role as a risk factor for neuroinflammation in MS.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:55:y:2024:i:1:p:46516-46519

DOI: 10.26717/BJSTR.2024.55.008631

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