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Clinical Pharmacology of Meropenem

Gian Maria Pacifici
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Gian Maria Pacifici: Professor of Pharmacology, Italy

Biomedical Journal of Scientific & Technical Research, 2024, vol. 55, issue 2, 46873-46883

Abstract: Meropenem is a carbapenem antibiotic and has a broader spectrum of activity than most β-lactam antibiotics, does not require co-administration with cilastatin because is not sensitive to renal dipeptidase, is available for intravenous infusion, is renally cleared, and the dose of meropenem is 1 or 2 grams thrice-daily. The efficacy and safely of meropenem, the prophylaxis with meropenem, the treatment of bacterial infections with meropenem, and the trials conducted with meropenem have been reviewed. The pharmacokinetics of meropenem have been studied in patients with serve sepsis or with septic shock and in healthy subjects and the mean elimination half-life of meropenem is 3.30 and 0.61 hours (P-value

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:55:y:2024:i:2:p:46873-46883

DOI: 10.26717/BJSTR.2024.55.008684

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