Reaction to Azithromycin, Between Hypereosinophilia and Charcot- Leyden Crystals- Case Report of a Pediatric Case

M Martini, A Ariano and E Parisio
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M Martini: Pediatric Unit, S. Donato Hospital, Arezzo, Italy
A Ariano: Pediatric Unit, Azienda Ospedaliera Universitaria Siena, Italy
E Parisio: Microbiology Unit S.Donato Hospital, Arezzo , Italy

Biomedical Journal of Scientific & Technical Research, 2024, vol. 55, issue 4, 47199-47202

Abstract: The Charcot-Leyden (CL) crystals, needle-shaped bipyramidal crystals, are present contextually with a high tissue infiltration of eosinophils. They are formed when galectin-10 crystalises at an intracellular or extracellular level during eosinophilic ETosis* (*Extracellular Trap cell death), an active cell death process involving the destruction of the cell nucleus and plasma membrane with the release of chromatin structures similar to cobwebs [1-3]. Hypereosinophilia, or rather, an eosinophilic count greater than 1.5 x 10^9/L, is typical in cases of hypersensitivity. An exemplary case that caught our attention in July 2023, was that of M., a 4-year-old girl with gastrointestinal symptoms combined with an elevated degree of eosinophilia equal to a count of 18.66*10^9/L and Charcot-Leyden crystals taken from a stool sample.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:55:y:2024:i:4:p:47199-47202

DOI: 10.26717/BJSTR.2024.55.008733

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