Selective Peroxisome Proliferator-Activated Receptor-α Modulator K-877 Stimulated the Expression of ABCA1 in Pancreatic Beta Cells in a Glucotoxic State

Kensaku Fukunaga, Hitomi Imachi, Jiang Wenyi, Toshihiro Kobayashi, Takanobu Saheki, Takafumi Yoshimura, Hao Tian Zhang, Seisuke Sato, Nao Saheki, Koji Murao and Jingya Lyu
Additional contact information
Koji Murao: Department of Endocrinology and Metabolism, Faculty of Medicine, Kagawa University, Japan
Jingya Lyu: Department of Physiology, School of Medicine, Jinan University, China

Biomedical Journal of Scientific & Technical Research, 2024, vol. 56, issue 2, 47904-47913

Abstract: ATP-binding cassette protein A1 (ABCA1) is a critical regulator of cholesterol and phospholipid efflux from cells to HDL. Additionally, ABCA1 is important for insulin secretion, as evidenced by impaired glucose tolerance and decreased insulin secretion in mice lacking ABCA1 in pancreatic β cells. Long-term hyperglycemia in type 2 diabetes mellitus, a phenomenon that causes dysfunction of pancreatic β-cells and insulin resistance, is called “glucotoxicity†and is clinically important as it aggravates diabetes. Here, we investigated the effects of pemafibrate (K-877), a novel selective PPARα modulator, on insulin secretion under glucotoxic conditions.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
References: Add references at CitEc
Citations:

Downloads: (external link)
https://biomedres.us/pdfs/BJSTR.MS.ID.008829.pdf (application/pdf)
https://biomedres.us/fulltexts/BJSTR.MS.ID.008829.php (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:56:y:2024:i:2:p:47904-47913

DOI: 10.26717/BJSTR.2024.56.008829

Access Statistics for this article

Biomedical Journal of Scientific & Technical Research is currently edited by Robert Thomas

More articles in Biomedical Journal of Scientific & Technical Research from Biomedical Research Network+, LLC
Bibliographic data for series maintained by Angela Roy ().