Targeting HK2 in Anticancer Therapy

Karolina Juszczak and Krzysztof Walczak
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Krzysztof Walczak: Department of Organic Chemistry, Bioorganic Chemistry and Biotechnology, Faculty of Chemistry, Silesian University of Technology, Poland

Biomedical Journal of Scientific & Technical Research, 2024, vol. 56, issue 3, 48032-48051

Abstract: Altered glucose metabolism is characteristic of many cancer cells, especially in the hypoxic zone of solid tumours, which is associated with a poor prognosis. Hexokinase (HK) is an enzyme involved in the first step of glycolysis, the phosphorylation of 6-OH in glucose molecules. Hexokinase 2 (HK2) is one of the isoforms overexpressed in cancer cells. In addition, HK2 binds to the voltage-dependent anion channel 1 (VDAC1) located on the outer mitochondrial membrane, protecting the cancer cell from apoptosis.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:56:y:2024:i:3:p:48032-48051

DOI: 10.26717/BJSTR.2024.56.008847

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