Melatonin Enhances the Efficacy of Cdk4/6 Inhibitor in Breast Cancer Cells Via Down-Regulating the Expression of Cyclind1

Zhumei Zhuang, Qing Tang, Miaomiao Gong, Jinjin Pan, Xiaocheng Yuan and Yuhui Yuan
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Zhumei Zhuang: Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Haining 310058, China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou 310058, China; Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, P. R. China
Yuhui Yuan: The Second Affiliated Hospital, Institute of Cancer Stem Cell, Dalian Medical University, Dalian 116400, P. R. China

Biomedical Journal of Scientific & Technical Research, 2024, vol. 59, issue 5, 51992-52004

Abstract: Breast Cancer (BC) is the most common malignancy and cause of death among women. CDK4/6 inhibitor-Palbociclib (PD) isethionate is a new chemotherapeutic agent in the treatment of breast cancer that works through blocking retinoblastoma phosphorylation protein and regulating the retinoblastoma (RB)-E2F pathway to inhibit cell cycle in the G0/G1 phase. However, the toxicity and resistance of PD are the primary limiting factors of this therapeutic effect. Melatonin (MLT) exerts anti-tumor activity in BC and arrests the cell cycle in the G0/G1 phase.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2024
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DOI: 10.26717/BJSTR.2024.59.009367

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