Metformin Beyond Diabetes- Antimicrobial Potential Against Resistant Pathogens

Ingrid Thaís Nogueira dos Santos, André Luís Serra Barbosa, Gessiane dos Santos de Souza, Karina Raquel Guilhon Machado, Weldson Ricardo Silva Gomes and Camila Guerra Martinez
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André Luís Serra Barbosa: Undergraduate Student, Biomedicine, CEUMA University, Brazil
Camila Guerra Martinez: Postgraduate Program in Biosciences applied to Health, CEUMA University, Brazil

Biomedical Journal of Scientific & Technical Research, 2025, vol. 60, issue 1, 52278-52282

Abstract: Metformin, primarily used to manage type 2 diabetes mellitus (T2DM), improves insulin sensitivity and inhibits hepatic gluconeogenesis through AMP-activated protein kinase (AMPK) activation, regulating cellular energy homeostasis. It also affects mitochondrial respiration by inhibiting complex I, thereby altering ATP production and increasing intracellular AMP levels. Despite its widespread use, metformin can cause gastrointestinal side effects like nausea and diarrhea.

Keywords: Journals on Medical Drug and Therapeutics; Journals on Emergency Medicine; Physical Medicine and Rehabilitation; Journals on Infectious Diseases Addiction Science and Clinical Pathology; Open Access Clinical and Medical Journal; Journals on Biomedical Science; List of Open Access Medical Journal; Journals on Biomedical Engineering; Open Access Medical Journal; Biomedical Science Articles; Journal of Scientific and Technical Research (search for similar items in EconPapers)
Date: 2025
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Persistent link: https://EconPapers.repec.org/RePEc:abf:journl:v:60:y:2025:i:1:p:52278-52282

DOI: 10.26717/BJSTR.2025.60.009408

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