GCMS and ADME Profiling of Extract from Seeds of Passiflora edulis

Yashmitha S. Raj, Aishwarya Patil, Dhanya Bhat and Sharad S. Achar
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Yashmitha S. Raj: Department of Biotechnology, Padmashree Institute of Management and Sciences, Bengaluru 560060, India
Aishwarya Patil: Department of Biotechnology, Padmashree Institute of Management and Sciences, Bengaluru 560060, India
Dhanya Bhat: Department of Biotechnology, Padmashree Institute of Management and Sciences, Bengaluru 560060, India
Sharad S. Achar: Department of Biotechnology, Padmashree Institute of Management and Sciences, Bengaluru 560060, India

Inventum Biologicum: An International Journal of Biological Research, 2025, vol. 5, issue 1, 1-5

Abstract: Passiflora edulis is a tropical fruit from the family passifloraceae. It is used as a traditional medicine in the treatment of several ailments. However, preliminary studies and several literature have mentioned these seeds to possess huge medicinal properties. This study is based on Gas Chromatography-Mass Spectrometry (GCMS) and in-silico techniques (ADME) applied to identify the bioactive phytocompounds present in extracts of the seeds in the fruit. The parameters considered for analysis were molecular weight, lipophilicity, GI absorption, water solubility, drug-likeness, Lipinski rule of 5, blood-brain barrier permeability, synthetic accessibility, bioavailability, and lead likeness. Among the eleven phytocomponents subjected to ADME analysis, ten of them were found to possess medicinal properties and four were identified as novel to these extracts. The compounds found in the GCMS analysis were propanedioic acid, oxirane derivative, anthranilanilide, a cytotoxic agent, an anticancer agent, and an antiproliferative agent. The chemical compounds present in the seeds impart them with medicinal properties, which would allow one to understand the relationship between the different bioactive compounds in seeds and the human body. Further studies need to be performed to identify its potential in ameliorating the neurological properties.

Keywords: ADME; GCMS; Passiflora edulis; Phytocompound (search for similar items in EconPapers)
Date: 2025
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