Prognostic Factors and a Nomogram Predicting Overall Survival in Muscle-invasive Bladder Cancer

Mu-an Ling, Bai-yun Gao, Wen-jun Yin, Jian-wen Wei, Song-bo Li and Bin Pan

International Journal of Sciences, 2022, vol. 11, issue 03, 24-28

Abstract: Muscle-invasive bladder cancer (MIBC) is a common type of bladder cancer characterized by a poor prognosis. The aim of this study was to establish a nomogram predicting the overall survival (OS) for patients with MIBC. All the 14,393 cased with MIBC were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The patients were randomly divided into training group and testing group with a 1:1 ratio. Then, we used The Kaplan-Meier to estimate the over survival OS of these patients. The Univariate and multivariate Cox analysis were performed to identify the independent risk factors related with OS, which were then used to construct a nomogram model in training group. And then the nomogram evaluated by the time-concordance index (C-index) and calibration curves in testing group. The result of Univariate and multivariate Cox analysis revealed that sex, race, N stage, M stage, surgery, radiotherapy, and chemotherapy were independent prognostic factors associated with OS. A nomogram was established using these factors with good discrimination and calibration.

Keywords: Bladder Cancer; Nonagram; Prognosis; Risk Factor (search for similar items in EconPapers)
Date: 2022
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DOI: 10.18483/ijSci.2559

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