Association of Anemia with Cardiovascular disease in patients with Diabetic Nephropathy with normal GFR

Khurshid Ahmad Khan and Professor Javed Akram

International Journal of Sciences, 2012, vol. 1, issue 12, 134-152

Abstract: Background: Anemia is recognized as an independent cardiovascular disease (CVD) risk factor in diabetic patients with end stage renal disease. However, it is not known whether anemia associated with early diabetic nephropathy increases CVD risk.Objective: To assess the effect of anemia on CVD risk in patients with Stage 1 chronic kidney disease (CKD).Materials and Methods: Cross sectional analysis of 2,502 diabetic patients with stage 1 CKD. Demographic, clinical and laboratory data were collected from two teaching hospitals affiliated with medical university in Lahore, Pakistan.Results: Of the 2,502 diabetic patients examined, 96% had type 2 diabetes. Age (years) = 64.2 ± 0.2, BMI= 29.6±0.2, duration of diabetes (years) = 9.3± 0.17, Hemoglobin A1C (A1C) % =7.8±0.04. Males represented 83.2% of the cohort.The CVD group included 909 (36.3%) of the total cohort and had a significantly lower mean serum hemoglobin (g/dl) (12.9±0.05 Vs 13.4±0.04, p 30 mg/gm creatinine and normal GFR (>90 ml/min/1.73m2). Using the National Kidney Foundation (NKF) threshold Hb of 12 g/dl for initiation of work up for anemia in chronic kidney disease, in our logistic regression model the odds ration (OR) for CVD in patients with Hb

Date: 2012
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