PERK Signaling Pathway Involved in Lactic Acid Induced Astrocyte Damage

Jian-Zhong Zhang, Li Jing, Ru Yan, Xiang-Mei Cao, Qing-Ping He and P. Andy Li

International Journal of Sciences, 2014, vol. 3, issue 10, 29-34

Abstract: Diabetes is an important modifiable risk factor for cerebral ischemic stroke. It increases infraction area and restrains astrocyte activation. Meanwhile, hyperglycemia increase lactic acid and decreases pH. Lactic acid may partially be accountable for the detrimental effects of diabetes on ischemic stroke. The objective of this study was to investigate the effect of lactic acid on astrocyte viability and to explore the potential mechanisms that lactic acid enhances astrocyte cell death. Astrocytes were challenged by various concentrations of lactic acid (0, 2.5, 5，10 and 15 mM). Cell viability and PERK pathway were examined. The results showed that lactic acid resulted in astrocyte death (p

Keywords: Acidosis; Astrocyte; Lactic acid; GRP78; PERK (search for similar items in EconPapers)
Date: 2014
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