Olfactory Discrimination Deficits in A53T Alpha-Synuclein Transgenic Mice at 3 Months

Yu Zhou, Zegang Ma and Qi Liu

International Journal of Sciences, 2015, vol. 4, issue 10, 12-15

Abstract: Parkinson’s disease (PD) is a kind of typical neurodegenerative diseases. Previously, clinical studies have showed that deficits in olfactory and cognitive functions precede motor-symptoms in PD. However, the mechanisms of olfactory discrimination deficits in early stage of PD is still unknown. In this study, we aimed to clarify the characteristics of olfactory deficits in A53T transgenic mice and test the possible mechanisms involved. By the elevated plus maze and bedding test, we showed that A53T transgenic mice at 3 months exhibit no hyperactivity behavior. Olfactory discrimination test indicated wild-type mice spent more time in old bedding than in new bedding during 5 min test (*P

Keywords: Parkinson’s Disease; Olfactory Discrimination; Fine Odor Discrimination; Hyperactivity (search for similar items in EconPapers)
Date: 2015
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DOI: 10.18483/ijSci.854

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