Expression and Significance of Beclin-1 and Bcl-2 in Gastric Cancer

Mei Lin, Wenmin Yuan, Xiaohui Sun and Zhiqiang Qin

International Journal of Sciences, 2015, vol. 4, issue 12, 58-61

Abstract: Objective To investigate the role and correlation of Beclin-1 and Bcl-2 in the occurrence and progression of gastric cancer. Methods The expression of Beclin-1 and Bcl-2 in 78 cases of gastric cancer, 30 cases of atypical hyperplasia and 20 cases of chronic non-atrophic gastritis was examined by immunohistochemical staining. Results The positive rate of Beclin-1 in gastric cancer was significantly lower than those in atypical hyperplasia and chronic non-atrophic gastritis(χ2=9.298,7.437, P 0.05). The positive rate of Bcl-2 in gastric cancer was significantly higher than those in atypical hyperplasia and chronic non-atrophic gastritis(χ2=11.013, 15.278, P 0.05). The expression of Beclin-1 and Bcl-2 was significantly correlated with differentiation, depth of invasion and TNM staging(χ2=7.014~16.248, P>0.05), but not correlated with sex, age, tumor size, tumor location and metastasis(P>0.05). The expression of Beclin-1 was negatively correlated with Bcl-2 in gastric cancer(r=-0.396, P

Keywords: gastric cancer; Beclin-1; Bcl-2; autophagy; apoptosis (search for similar items in EconPapers)
Date: 2015
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DOI: 10.18483/ijSci.879

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