Whole Genome Microarray Analysis In Invasive Ductal Breast Cancer Revealed The Most Significant Changes Affect Chromosomes 1, 8, 17 And 20

Ivanka Dimova, Radka Tafradzhiska-Hadzhiolova, Svilen Maslyankov, Desislava Nesheva and Draga Toncheva

International Journal of Sciences, 2015, vol. 4, issue 01, 8-17

Abstract: Despite of the large number of molecular studies in breast cancer, the data are still insufficient for understanding its molecular pathogenesis. The dramatic development of genetics in recent years has made it possible to gain insight into the molecular mechanisms of tumorigenesis. The aims of the study was to determine the type, frequency and fine mapping of unbalanced genomic alterations in ductal carcinoma of the breast. For this study we have used tumor samples of invasive ductal breast cancer to be analysed by comparative genomic hybridization on DNA microarrays. Two approaches were applied in the analysis of significant unbalanced genomic changes: a) identification of clones which presented unbalanced changes (log2 T: H> +0.25 for gain and +0.5) or homozygous deletions (log2 T: H

Keywords: ductal breast cancer; array CGH; oncogenes and tumor-supressor genes (search for similar items in EconPapers)
Date: 2015
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